225Ac is an invaluable radionuclide for targeted alpha therapy; however, 227Ac is an impurity that may arise during synthesis. The study makes use of superconducting transition edge sensor microcalorimeters to measure the decay energies of these isotopes with high precision. This method allows for fine distinction of isotopic features vital for efficient targeted therapy.

Highlights:

• Utilized high-resolution microcalorimeters for decay energy spectroscopy.
• Detected fine isotopic features to distinguish between 225Ac and 227Ac.
• Showcased remarkable sensitivity in measuring 227Ac impurity at end-of-bombardment.

The research sets a precedent for using high-precision techniques to enhance the safety and efficacy of nuclear medicine procedures (read more). Fiber optic sensors, known for their sensitivity, could similarly be applied in such settings to detect minute changes, ensuring the quality and safety of radiopharmaceuticals.